Recent publications

• Lana D, Branca JJV, Delfino G, Giovannini MG, Casamenti F, Nardiello P, Bucciantini M, Stefani M, Zach P, Zecchi-Orlandini S, Nosi D. Morphofunctional Investigation in a Transgenic Mouse Model of Alzheimer's Disease: Non-Reactive Astrocytes Are Involved in Aβ Load and Reactive Astrocytes in Plaque Build-Up. Cells. 2023 Sep 12;12(18):2258. doi: 10.3390/cells12182258.

• Wurst Z, Birčák Kuchtová B, Křemen J, Lahutsina A, Ibrahim I, Tintěra J, Bartoš A, Brabec M, Rai T, Zach P, Musil V, Olympiou N, Mrzílková J. Basal Ganglia Compensatory White Matter Changes on DTI in Alzheimer's Disease. Cells. 2023 Apr 23;12(9):1220. doi: 10.3390/cells12091220.

• Lahutsina A, Spaniel F, Mrzilkova J, Morozova A, Brabec M, Musil V, Zach P. Morphology of Anterior Cingulate Cortex and Its Relation to Schizophrenia. J Clin Med. 2022 Dec 21;12(1):33. doi: 10.3390/jcm12010033.

• Řasová K, Bučková B, Prokopiusová T, Procházková M, Angel G, Marková M, Hrušková N, Štětkářová I, Špaňhelová Š, Mareš J, Tintěra J, Zach P, Musil V, Hlinka J. A Three-Arm Parallel-group Exploratory Trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive "facilitation and inhibition" physical therapy. Eur J Phys Rehabil Med. 2021 Dec;57(6):889-899. doi: 10.23736/S1973-9087.21.06701-0.

• Frýdlová P, Mrzílková J, Šeremeta M, Křemen J, Dudák J, Žemlička J, Minnich B, Kverková K, Němec P, Zach P, Frynta D. Determinate growth is predominant and likely ancestral in squamate reptiles. Proc Biol Sci. 2020 Dec 23;287(1941):20202737. doi: 10.1098/rspb.2020.2737.

• Sol D, Olkowicz S, Sayol F, Kocourek M, Zhang Y, Marhounová L, Osadnik C, Corssmit E, Garcia-Porta J, Martin TE, Lefebvre L, Němec P. Neuron numbers link innovativeness with both absolute and relative brain size in birds. Nat Ecol Evol. 2022 Sep;6(9):1381-1389. doi: 10.1038/s41559-022-01815-x.

Research focus of the department, Ph.D. studies and other activities

• Research focus of the department:

  
  

  Neuroscience (Alzheimer's disease, imaging techniques in neuroscience, Prof. Petr Zach)

  
  

  PGS students:

  
  

  Dr. Tanya Rai - collaborative project with NUDZ, ESO database, morphology of the parafactorial cortex in patients with schizophrenia (OR Neuroscience)

  
  

  Dr. Alexandra Morozova - magnetic resonance imaging of CNS vascular supply, quantification of perivascular spaces (PVS) in patients with Alzheimer's disease (OR Neuroscience)

  
  

  Dr. Nicoletta Olympiou - DTI study of the course and changes of fasciculus arcuatus and uncinatus fibers in patients with Alzheimer's disease (OR Neuroscience)

  
  

  Dr. Martin Sheremeta - CNS changes in metabolic syndrome in a rabbit MRI model (OR Physiology)

  
  

  Dr. Paolo Palma - Tracking the progression of schizoaffective disorder: longitudinal analysis of clinical, behavioral and brain biomarkers (OR Neuroscience) (supervisor Dr. Zaytseva)

  
  

  dr. Zdeněk Wurst - Analysis of memory structure connectivity in different types of CNS pathologies (OR Neuroscience) (supervisor dr. Mrzílková)

  
  

  Physical anthropology (growth of children, growth charts - RNDr. Jitka Riedlová)

  
  
  

  Experimental imaging of hard and soft tissues on micro-CT (the department is equipped with a Bruker Skyscan micro-CT scanner - MUDr. Jana Mrzílková)

  
  
  

  Research on amyotrophic lateral sclerosis in a transgenic mouse model - RNDr. Zdeněk Musil, Ph.D.

  
  
  

  Evolution of brain complexity and processing capacity in birds - Martin Kocourek, Ph.D.

  
  
  

  Clinical Anatomy - Prof. MUDr. Václav Báča, Ph.D.

• *Article Compensatory shift of white matter parameters of the subcalosal area and paraterminal gyrus on DTI in patients with Alzheimer's disease. Kuchtová B, Wurst Z, Mrzílková J, Ibrahim I, Tintěra J, Bartoš A, Musil V, Kieslich K, Zach P. Curr Alzheimer Res. 2018;15(6):590-599. doi: 10.2174/1567205015666171227155510.

  
  

  *It was cited in the Correspondence section of the New England Journal of Medicine (IF=70): Fornix-Region Deep Brain Stimulation-Induced Memory Flashbacks in Alzheimer's Disease. N Engl J Med 2019; 381:783-785. DOI: 10.1056/NEJMc1905240.

  
  

  *International collaboration with the University of Florence - Dipartimento di Medicina Sperimentale e Clinica (DMSC), prof. Annamaria Morelli (metabolic rabbit syndrome, neurohistology of the rabbit CNS and MRI of the rabbit brain in collaboration with IKEM, Assoc. ing. Daniel Jirák), prof. Daniele Nosi (role of astroglia in a transgenic mouse model of Alzheimer's disease), Dr. Daniele Lana (Department of Neuropharmacology, UNIFi) (neuroimmunohistochemistry in an animal model of Alzheimer's disease)

  
  

  *International collaboration with the University of Sydney, School of Medical Sciences [Neuroscience], Laboratory of Molecular Neuroscience and Dementia (prof. Damian Holsinger, pharmacological as well as non-pharmacological interventions that can bring about treatments for Alzheimer's disease)

  
  

  *Collaboration with the Faculty of Philosophy of Charles University: Caenorhabditis elegans and the influence of Lithium 6 and 7 isotopes on motility - significance for the change of isotope concentration ratio in drugs for bipolar disease (Marie Macůrková, Ph.D.)

  
  

  *Collaboration with NUDZ, Klecany: dr. Filip Španiel, analysis of magnetic resonance images of brains from ESO and HYDRA database in patients with schizophrenia and Alzheimer's disease, morphometric studies focused on the analysis of grey and white matter structure; dr. Karel Valeš: brain energy project, research on mTOR metabolic pathway, metabolic syndrome in animal model and changes in grey and white matter of CNS

  
  

  *Interesting article: Sol, D., Olkowicz, S., Sayol, F., Kocourek, M., Zhang, Y., Marhounová, L., Osadnik, C., Corssmit, E., Garcia-Porta, J., Martin, T. E., Lefebvre, L., & Nemec, P. (2022). Neuron numbers link innovativeness with both absolute and relative brain size in birds. Nature Ecology & Evolution, 6(9), 1381-1389