Project:

Characterization of metabolic properties of adipose tissue in response to fasting, ketogenic diet and in cancer-associated cachexia

Mentor (Advisor):

Lenka Rossmeislová, PhD, Michaela Šiklová, PhD

Department:

Department of pathophysiology

Contact information:

Project Narrative:

Excessive accumulation of adipose tissue (AT) as well as its abnormal catabolism induced by cancer is associated with the development of a number of metabolic diseases, resp. can be the cause of death. Both conditions trigger metabolic dysfunction of AT- obesity causes suppression of de novo lipogenesis, cancer associated cachexia is linked with deregulation of lipolysis. The PhD project is therefore focused on the study of these processes on a model of simple fasting, isocaloric ketogenic diet and cancer associated cachexia.

Requirements for student applicants:

The candidate must have a biological, biochemical or medical type of education (MSc, MD) before commencing PhD studies. We are looking for highly motivated individuals for whom science is more a mission than a job.