Project:

Glucokinase as the cause of diabetes, hyperglycemia and familial cancer

Mentor (Advisor):

RNDr. Petr Heneberg, Ph.D.

Department:

2nd Department of Internal Medicine

Contact information:

; tel. 775 311 177

Project Narrative:

The project aims to elucidate the role of mutations in the glucokinase encoding gene in the development and progression of monogenic diabetes, familial hyperglycemia and cancer. This enzymologic Ph.D. project should be conducted in close cooperation with other members of the lab and will aim to elucidate the mechanisms by which individual mutations act and will attempt to uncover the possibilities for experimental therapy of effects of glucokinase mutations by pharmacotherapeutics and gene therapy.

Requirements for student applicants:

The topic can be adjust to a large extent to the focus of your prior education (general medicine, pharmacy, biochemistry, molecular biology and genetics). We expect enthusiasm and proactive approach to the project. Our laboratory is able to provide surplus scholarships above the standard sums granted by the university, and we also offer the opportunity of a part-time work in the lab.