Project:

Processing and long term preservation of unused parts of the donor cornea for further use in ophthalmology

Mentor (Advisor):

MUDr. Miroslav Veith, Ph.D.

Department:

Ophthalmology dep.

Contact information:

Project Narrative:

Intravitreal anti-VEGF agents are also used for treatement diseases that may occur in young patients. Several cases of intravitreal anti-VEGF therapy in breastfeeding women have been reported in the literature. Nevertheless, there is still a lack of more research into whether anti-VEGF drugs pass into breast milk and whether they affect postpartum growth and newborn development.

Methods: In the lactating rat model, the transfer of various intravitreally administered anti-VEGF agents into breast milk will be monitored. The experimental groups will be compared with a control group in which saline will be administered intravitreally. At several time intervals after intravitreal administration, a blood and breast milk sample will be taken from the nursing mother to detect the levels of drug and VEGF administered. Furthermore, the postnatal development of breastfed infants in individual groups will be compared. The output of the project should be pilot data on the penetration of individual anti-VEGF preparations into breast milk and their influence on the postnatal development of breastfed infants.

Requirements for student applicants:

Graduated medical doctor