Project:

Understanding cellular and molecular interactions in adipose tissue: Implications for metabolic health in diseases associated with the changes of adiposity

Mentor (Advisor):

Mgr. Lenka Rossmeislová, PhD

Department:

Department of Pathophysiology

Contact information:

Project Narrative:

Adipose tissue (AT) plays a crucial role in maintaining human energy homeostasis. Its structural and functional properties, both at the organ level and in terms of its cellular and interstitial components, can undergo significant changes in pathological conditions such as obesity, cachexia and lymphedema. These alterations can further worsen these conditions, highlighting the importance of understanding AT dynamics.

This PhD research aims to investigate changes in the properties of AT, focusing on intercellular interactions across different phenotypic human groups, responses to acute interventions, and in vitro cellular models. Particular attention will be given to the AT interstitium, whose responses to metabolic and external stimuli remain poorly understood and are influenced by interactions between adipocytes, immune cells, and endothelial cells.

A variety of physiological and molecular biology methods will be employed to explore these interactions. The research will be conducted under the supervision of an experienced PhD mentor (with four successfully defended students and a fifth nearing defense) within a dynamic, small research team.

Requirements for student applicants: