ECRIN je evropská výzkumná infrastruktura, která usnadňuje výzkumným pracovníkům vznik a provedení mezinárodních klinických hodnocení v Evropě. Svoji činnost uskutečňuje prostřednictvím propojení s ECRIN národními evropskými korespondenty, národními sítěmi jednotek klinických hodnocení a prostřednictvím svých...

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Lektor / lektorka se zaměřením na stomatologii / endodoncii Předpokládaný nástup: březen 2026 nebo dle dohody Předpokládaný úvazek: úvazek 0,1 dle dohody

Workplace: Department of Experimental Biology, Faculty of Science, Masaryk University in Brno, Czech Republic Type of Contract: temporary position with 3-year contract (with possible extension), academic Working Hours: 0,3 FTE (part-time employment of 12 hours per week) Expected St

Raman optical activity is a dynamically evolving vibrational spectroscopy, suitable, for example, for structural studies of biomolecules. Spectral interpretations are usually based on molecular dynamics and quantum-chemical methods. These need to be adapted for a particular experiment. We will focus on theoretical description of resonance and...

Recent discoveries of non-canonical RNA caps, such as NAD and CoA, have led to a fundamental reassessment of the structural diversity of RNA across all domains of life. In our research group, we have identified an entirely new class of RNA caps—dinucleoside polyphosphates (NpnN)—present in both bacterial and eukaryotic cells. This discovery...

The recent discovery of non-canonical RNA caps, such as NAD and CoA, has fundamentally changed our understanding of the structural and functional diversity of RNA in all types of cells. In our laboratory, we have recently identified a new type of RNA cap in mammalian cells—diadenosine tetraphosphate (Ap4A). Ap4A has been known for several...

Quantum nanosensors offer significant advantages over classical sensors, including high sensitivity and resolution. One type of such quantum nanosensor is photoluminescent nanoparticles, whose detection is based on monitoring luminescence changes in response to external stimuli. The goal of the project is to read optical nanosensors using pulsed...

Photoluminescent nanodiamonds represent a novel type of quantum biosensor that exploits changes in luminescent properties in response to external stimuli. Compared to classical sensors, they offer the benefits of high sensitivity and resolution but are often nonspecific. The aim of the project is to chemically functionalize these sensors for...

The topic of the dissertation will be the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified XNA oligonucleotides will be prepared and tested as potential therapeutics.

The topic of the dissertation will be the enzymatic synthesis of hypermodified xeno-nucleic acids and their use in aptamer selection. It will be necessary to develop enzymatic synthesis of modified XNA libraries, selection of binding sequences, reverse transcription into DNA and sequencing. The goal will be the development of stable aptamers...

The aim of the thesis will be to synthesize PROTACs for several kinases, which are validated targets in oncology and in CNS disorders. It will be focused on linker optimization, selection of ligase ligands and specificity for target kinase. Our recently developed highly selective small molecule heterocyclic kinase inhibitors will serve as a...

The aim of the thesis will be the development of an efficient enzymatic synthesis of oligonucleotides on solid support. Diverse solid supports and linkers will be tested for attachment of templates and will be used for primer extension with either denaturaion or cleavage of the resulting oligonuclotides by endonucleases. Methods will be then...

The aim of the thesis will be the enzymatic synthesis of DNA bearing diverse sugars or glycans. The project will start with synthesis of diverze sugar- or glycan-linked dNTPs and their enzymatic incorporation into DNA. It will be followed by development of site-specific methods and syntheses of DNA probes bearing glycans at specific positions for...

The dissertation will focus on the mechanistic principles underlying photogearing at the molecular scale, i.e. the conversion of a light-driven primary motion into a mechanically coupled secondary rotation. While many molecular systems undergo photoinduced conformational changes, only a limited number enable controlled transmission of motion...

Our group recently developed nucleophilic aromatic substitutions for synthesis of drug-like atropisomers, chiral conformational isomers originating from restricted single bond rotation. In this context, we discovered a fluoride-catalyzed strategy that is remarkably efficient. In this PhD thesis, we will explore this reactivity for synthesis of...

Critical raw materials such as rare earth elements and other strategically important metals are indispensable for modern technologies, yet are increasingly difficult to secure in a sustainable manner. This Ph.D. project will focus on the rational design and synthesis of tailored chelating agents capable of selectively binding and recovering the...

Excited state multiplicity plays a critical role in governing photochemical reactivity. Most of the excited organic molecules can exist either in the singlet or triplet excited state. Singlets are typically short-lived (~ns) and exhibit zwitterionic character, whereas triplet excited states, with their diradical-like nature, are significantly...

The multiplicity of excited states in organic photochemistry is governed by electron spin and its interactions. Excited molecules most commonly occur in singlet or triplet states; interconversion between them and the resultant reactivity are controlled by spin-selection rules and the magnitude of spin–spin interactions. In particular,...

The aim of the project is to develop the synthesis of new warped and chiral nanocarbons such as helical pi-conjugated macrocycles or cycloarenes. The chiral compounds will be prepared in optically pure form by resolution of racemates or by asymmetric synthesis. Their (chir)optical properties, self-assembly in 2D/3D space, aromatic character, and...

As part of the doctoral project, a new class of helically chiral metal complexes for enantioselective catalysis will be developed. The main part of the work will focus on their design and synthesis. The catalytic potential of the prepared systems will then be verified on model enantioselective transformations catalyzed by transition metals, in...

The aim of the project is to prepare new helical TADF and excimer luminophores derived from helicenes and to study their chiroptical properties in solution and thin films (in particular circularly polarized luminescence) in order to identify suitable materials for future CP-OLED design. Universit

Workplace: Department of Department of Experimental Biology, Faculty of Science, Masaryk University, Czech Republic Type of Contract: temporary position with 1-year contract with possible extension, academic Working Hours: 0,6 FTE (part-time employment of 24 hours per week) Expecte

Pracovní pozice vznikla za finanční podpory Evropské unie v rámci projektu LERCO s reg. číslem CZ.10.03.01/00/22_003/0000003, prostřednictvím Operačního programu spravedlivá transformace Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Laborant/techni

Doctoral study program: Biomedical Sciences Specialization: Molecular Medicine Supervisor: Mgr. Veronika Šandová, Ph.D. Topic title: Therapy-induced changes in CD20 expression and microenvironmental interactions in chronic lymphocytic leukemia Annotation:

Doctoral study program: Biomedical Sciences Specialization: Molecular Medicine Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic title: Long non-coding RNAs (lncRNAs) in microenvironmental interactions of B cell chronic lymphocytic leukemia Annotation:

Doctoral study program: Life Sciences Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Overcoming the Endosomal Barrier: Design Principles of Fusogenic Proteins for Lipid Vesicles Annotation: Cancer remains one of the leading causes of mortality worldwide, claim

Doctoral study program: Life Sciences Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Designing Coiled-Coil Peptides for Controlled Membrane Fusion and Intracellular Delivery Annotation: Most approved drugs act on cell-surface targets or enter cells passively.

Doctoral study program: Life Sciences Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Consultant: Miroslav Boudny, Ph.D. Topic title: Lymphoid microenvironment models and their use to study targeted therapy and resistance in B cell malignancies Annotation:

We are seeking a highly motivated PhD student to join an interdisciplinary research project focused on Midichloria, a unique intracellular symbiont capable of invading mitochondria of oocytes of several tick species, e.g. Ixodes ricinus. Despite its exceptional biology, the mechanisms underlying mitochondrial specificity of 

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení na obsazení pracovního místa Asistent / Asistentka se zaměřením na epidemiologii a ochranu veřejného zdraví Předpokládaný nástup: únor 2026 nebo dle dohody Před

Pracovní pozice vznikla za finanční podpory Evropské unie v rámci projektu LERCO s reg. číslem CZ.10.03.01/00/22_003/0000003, prostřednictvím Operačního programu spravedlivá transformace Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Excelentní pracovník /

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení na pozici: Odborný asistent / odborná asistentka se zaměřením na gastroenterologii Předpokládaný nástup: únor 2026 nebo dle dohody Předpokládaný úvazek: 5 % Požadavky

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení na obsazení pracovních míst Lektor / lektorka se zaměřením na infekční lékařství Předpokládaný nástup: únor 2026 nebo dle dohody Předpokládaný úvazek: 0,1 Kva

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Odborný asistent / odborná asistentka se zaměřením na mikrobiologii, parazitologii, genetiku a virologii Předpokládaný nástup: únor 2026 nebo dle dohody Předpokládan�

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Odborný asistent / odborná asistentka se zaměřením na hematoonkologii Předpokládaný nástup: únor 2026 Předpokládaný úvazek: 5% Požadujeme:

Doctoral study program: Life Sciences Supervisor: prof. Mgr. Richard Štefl, Ph.D., Topic title: Deciphering the Argonaute Loading Mechanisms in RNA-Silencing Pathways Annotation: Small RNAs are master regulators of gene expression in animals and plants. They guide Argo

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time /combined Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Mgr. Václav Šeda, Ph.D. Consulta

Doctoral study program: Life Sciences Form of study: doctoral full-time Supervisor: Mgr. Michal Šmída, Ph.D. Topic title: The role of mitochondria exchange through tunnelling nanotubes in the regulation of CAR-T cell activity Annotation: CAR-T cell

Jsme skupina rostlinných molekulárních biologů na CEITEC MU, hledající do našeho týmu nového kolegu/novou kolegyni na pozici   Laboratorní technik/technička   Kdo jsme? V naší laboratoři se zabýváme výzkumem hormonálních drah u rostlin, stejně jako optimalizací metod pro editaci genomu u rostlin...

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení na obsazení pracovního místa odborný/á asistent/ka se zaměřením na interní ošetřovatelství  Předpokládaný nástup: Únor 2026 nebo dle dohody Předpokládaný

Come to CEITEC MU in Brno and join us! We are passionate chemists at CEITEC Masaryk University looking for Two PhD Candidates/Students in Molecular Strategies for Anticancer Drug Delivery       About this position: We are seeking two highly motivated PhD candidates with a strong interest in understanding chemo

Come to CEITEC MU in Brno and join us! We are passionate chemists at CEITEC Masaryk University looking for PhD Candidate/Student in Computational Quantum Chemistry & Spectroscopy          About this position: Do you have a passion for understanding the electronic structure of molecules?

PhD position in Honey bee research Virus infections are found in virtually all honey bee colonies and, together with the parasitic mite Varroa, are considered the main causes of honey bee colony losses. Research has focused primarily on the Deformed wing virus (DWV), which has been well characterized in terms of its pathogenicit

Tajemník Přírodovědecké fakulty Masarykovy univerzity vypisuje výběrové řízení na obsazení pracovního místa: Výzkumník/výzkumnice Pracoviště: RECETOX, Přírodovědecká fakulta Masarykovy univerzity v Brně Pracovní poměr: na dobu určitou s úvodní pracovní smlouvou

Bursar of the Faculty of Science, Masaryk University announces an open competition for the position Ph.D. student – Machine learning-based tools for multiparametric enzyme optimisation Workplace: RECETOX, Faculty of Science, Masaryk University in Brno, Czech Republic Type of Contract: temp

PhD position in Aquatic Chemical Ecology Characterizing zooplankton infochemicals and their effects on cyanobacterial traits (Shared position between the University of South Bohemia and the Institute of Microbiology of the Czech Academy of Sciences, Czech Republic) We are seeking an enthusiastic PhD student to join our res

Join a vibrant international research community at Masaryk University’s Faculty of Medicine, a holder of the HR Excellence in Research Award. Work with leading principal investigators, access cutting-edge infrastructure, and develop your independent scientific profile in one of Europe’s most dynamic research hubs. Research Areas:

HLEDÁME VÝZKUMNÉHO PRACOVNÍKA SE ZKUŠENOSTÍ V ADMINISTRACI SBĚRU DAT VĚDECKÝ PROJEKT NA ODCHODY ZDRAVOTNÍKŮ A PŘECHODY ZE VZDĚLÁVACÍHO SYSTÉMU DO PRAXE NABÍZÍME: Moderní pracovní prostředí v kampusu 2. LF v Motole Možnost sdílení a předávání zkušen

Doctoral study program: Life Sciences Supervisor: RNDr. Radek Marek, Ph.D. Topic title: Junctions in noncanonical forms of nucleic acids Annotation: The project is focused on detailed structural characterization of short oligonucleotides in noncanonical forms clipped to

Doctoral study program: Life Sciences Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Lipid nanoparticles in drug delivery Annotation: With nearly 10 million lives claimed annually, cancer remains one of the leading causes of mortality worldwide, highlighting t

Doctoral study program: Life Sciences Supervisor: RNDr. Petr Tesina, Ph.D. Topic title: Mechanisms of human translation control Annotation: Co-translational quality control is triggered as a response to translational stalling events. Yet, different molecular mechanisms

Doctoral study program: Life Sciences Supervisor: Pavel Plevka Topic title: Mechanisms of neutralization of TBEV by polyclonal and monoclonal antibodies Annotation: Tick-borne encephalitis virus (TBEV) is a medically significant flavivirus causing severe neurological di

Doctoral study program: Life Sciences Supervisor: Dr. Dalibor Blazek, PhD. Topic title: Mechanistic Roles of Cyclin-Dependent Kinase 12 (CDK12) in Transcription Regulation and Cancer Biology. Annotation: CDK12 is a transcriptional cyclin-dependent kinase (CDK) found mut

Doctoral study program: Life Sciences Supervisor: Lukas Trantirek, Senior Research Group leader (UCO: 8725) Consultant: Anirban Ghosh, Senior Researcher (UCO: 246285), Topic title: Molecular insights into the G-quadruplex–helicase interactome and its functional implicati

Doctoral study program: Life Sciences Supervisor: Lukas Trantirek, Senior Research Group leader (UCO: 8725) Consultant: Silvie Trantirkova, Senior Researcher (UCO: 118502), Topic title: Protein in-cell NMR Spectroscopy in 3D Stem Cell-Derived Human Organ Models

Doctoral study program: Life Sciences Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Consultant: Vaclav Seda, Ph.D. Topic title: REGULATION OF CELL MIGRATION IN B CELL LEUKEMIAS AND LYMPHOMAS Annotation: The project goal is to understand the molecul

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Mgr. Miroslav Boudny, Ph.D. Consultant:

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic ti

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: RNDr. Josef Večeřa, Ph.D. Topic title:

Doctoral study program: Life Sciences Supervisor: Pavel Plevka Topic title: Structural characterization of leptophage replication cycle Annotation: Despite decades of study, important aspects of phage replication cycles, such as the mechanism of genome delivery, initiat

Doctoral study program: Life Sciences Supervisor: Pavel Plevka Topic title: Structure-guided phylogeny of tailed bacteriophages Annotation: Tailed phages are a diverse group of viruses abundant in all econiches as revealed by recent metagenomic studies. In the past ten

Institute of Soil Biology and Biochemistry of the Biology Centre CAS, České Budějovice, welcomes applications for a four-year PhD student position in soil fauna effects on soil organic matter stability. We are seeking a mo

Děkanka Přírodovědecké fakulty Ostravské univerzity vypisuje výběrové řízení na obsazení pracovního místa na Katedře biologie a ekologie Vedoucí výzkumné skupiny v oblasti virologie, excelentní pracovník projektu LERCO Jedná se o pracovní místo obsazované v souladu s podmínkami pr