Peatland Ecology Group, Department of Ecosystem Biology, Faculty of Science, University of South Bohemia, České Budějovice, CZECHIA https://www.prf.jcu.cz/en/peatlands We are seeking a postdoctoral researcher to join our Peatland Ecology Group to investigate plant–soil

POSTDOCTORAL FELLOWSHIP OPPORTUNITY MSCA Postdoctoral Fellowship & EMBO Postdoctoral Fellowship Metabolomic data analyst / Molecular Biologist (m/f/d) Laboratory of Cardiometabolism Institute of Physiology of the Czech Academy of Sciences, Prague About the Position

Academic Position at the Department of Agrochemistry, Soil Science, Microbiology and Plant Nutrition, Faculty of AgriSciences Research Area: soil microbiology The Department of Agrochemistry, Soil Science, Microbiology and Plant Nutrition specializes in the area of plant nutrition focusing on nitrogen and sul

Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position: PhD Positions in Quantitative Imaging of Ciliary Transport The Institute of Biotechnology (

Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position: Postdoctoral Researcher in Molecular Transport Dynamics The Institute of Biotechnology (IBT

Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position: Postdoctoral Researcher in Dynamic Control of Ciliary Transport The Institute of Biotechnol

Background: Viral infections are found in virtually all honey bee colonies worldwide. Together with the parasitic mite Varroa, they are considered the main causes of honey bee colony losses. Research has focused primarily on the Deformed wing virus (DWV), which has been well characterized in terms of it

Non-academic research position at the Department of Agrochemistry, Soil Science, Microbiology and Plant Nutrition, Faculty of AgriSciences Research Area: plant nutrition The Department of Agrochemistry, Soil Science, Microbiology and Plant Nutrition specializes in plant nutrition, focusing on nitrogen and sul

Come to CEITEC MU in Brno and join us! We are passionate structural biologists (focused on NMR spectroscopy of nucleic acids) at CEITEC, looking for Postdoctoral Research Fellow in Non-Coding Genome Research group   About this position: We are seeking a highly motivated Postdoctoral Researcher to join our team! The...

POSTDOCTORAL FELLOWSHIP OPPORTUNITY MSCA Postdoctoral Fellowship Laboratory of Cholinergic Signaling Institute of Physiology of the Czech Academy of Sciences, Prague About the Position We are seeking a highly motivated postdoctoral researcher with a background in neuroscience to

Project: UWB Returns The project is primarily focused on increasing the professional competences of researchers returning to the scientific/research environment after a career break. The CBAG return scheme has been announced, as part of the UWB RETURNS project, where applicants can apply for return grants with implementation from September 1,...

Academic Position at Mendel University - Mendeleum - Department of Genetics, Faculty of Horticulture Research Area: plant mycology, molecular genetics, microscopy, bioinformatics The focus of the research lies in the area of plant biotechnology, where molecular genetics methods are utilized for the pr

Doctoral study program: Life Sciences Supervisor: doc. RNDr. Mgr. Jozef Hritz, Ph.D. Topic title: Structural and Functional Characterization of Tau Fibrils and Their Regulation by Interaction Partners Annotation: Tau is an intrinsically disordered microtu

Supervisor: Iryna Kozmikova Co-supervisor: Jan Paces Project description The project will use bioinformatic analysis together with comparative approaches to individual cells, and machine learning to investigate how the vertebrate head evolved and what mechanisms control cell fate specifica

Join a global team and supportive environment, work with top-notch facilities, and enjoy vibrant Prague! If you are interested in the genetics, genomics or bioinformatics, structure and function of cells, tissues and organisms, you will find your niche at IMG. We study molecular mechanisms in a wide-range of model systems includ

POSTDOCTORAL FELLOWSHIP OPPORTUNITY MSCA Postdoctoral Fellowship & EMBO Postdoctoral Fellowship Postdoctoral Bioinformatician / Computational Biologist (m/f/d) Laboratory of Neuroepigenetics Institute of Physiology of the Czech Academy of Sciences, Prague About the Posi

POSTDOCTORAL FELLOWSHIP OPPORTUNITY MSCA Postdoctoral Fellowship & EMBO Postdoctoral Fellowship Experimental Neuroscientist / Molecular Biologist (m/f/d) Laboratory of Neuroepigenetics Institute of Physiology of the Czech Academy of Sciences, Prague About the Position

Supervisor Vladimír Varga Project description Cilia are elongated organelles on the surface of many human cell types. They have important motility, signaling and sensory roles, and their malfunctioning causes diseases called ciliopathies. There are two major types of cilia, motile and primary cilia. Their

Supervisor Zuzana Sumbalová Koledová Project description Lactation is a critical physiological process requiring precise coordination of cellular functions, including DNA replication, transcription, and the DNA damage response, to support milk production. This PhD project aims to unravel the molecular me

Supervisor António Pires da Silva Baptista Project description Lymphoid-myeloid crosstalk and cooperation are essential for host protection against infection. Involving multiple signaling pathways, this communication is thought to involve sensing of infection by myeloid cells which in turn activate lympho

Supervisor António Pires da Silva Baptista Project description Immune tolerance involves self-reactive T cell deletion in the thymus, and peripheral constraint of self-reactive escapees by regulatory T cells (Tregs). The latter occurs mostly in secondary lymphoid organs such as lymph nodes, where Tregs ac

Supervisor Teije Corneel Middelkoop Project description Cell polarization is essential for many biological processes such as asymmetric cell division, cell migration and body axis establishment, and can be observed throughout the tree of life. Cell polarization can be achieved 1) biochemically, via network

Supervisor Libor Macůrek Project description Genome instability is one of the drivers of cellular transformation and cancer development. Tumor suppressor p53 prevents proliferation of cells with damaged DNA and eliminates them either by programmed cell death or by induction of a permanent cell cycle arres

Supervisor Lucie Láníková Project description Hematopoiesis is a highly organized and dynamic process of blood cell production, progressing hierarchically from hematopoietic stem cells (HSCs) through multipotent progenitors to fully differentiated cells of the myeloid and lymphoid lineages. This system

Supervisor Filip Šenigl Project description Somatic hypermutation (SHM) is a key process in diversification of antibodies. This process is initiated by cytosine deamination by the activation-induced cytidine deaminase (AID) and completed by error-prone processing of the resulting uracils. Though SHM aims

Supervisor Martin Gregor Project description Metastasis critically depends on the ability of single tumour cells to establish and maintain cytoskeletal polarity in three-dimensional environments and in suspension. Recent studies have identified intrinsic actin- and myosin-rich cortical poles and associated

Supervisor Martin Gregor Project description Hepatocellular carcinoma (HCC) is an aggressive liver malignancy with limited therapeutic options. Tumor progression critically depends on cytoskeletal organization and mechanotransduction, processes in which the cytolinker protein plectin plays a central role.

Supervisor Martin Gregor Project description Plectin is a key cytoskeletal crosslinker required for mechanical stability and signaling in skeletal muscle and heart. Mutations in the plectin isoform P1f cause limb-girdle muscular dystrophy accompanied by progressive cardiomyopathy. Due to the large size of

Supervisor Meritxell Alberich Jordà Project description Hematopoietic stem and progenitor cells (HSPCs) constitute a rare yet indispensable population within the bone marrow that sustains lifelong blood cell production. Preservation of their integrity and functional capacity is essential for normal hemato

Supervisor Meritxell Alberich Jordà Project description Hematopoietic stem and progenitor cells (HSPCs) are responsible for lifelong maintenance of the blood system, yet their function progressively declines with age. Chronic inflammation, a hallmark of aging, represents a major and persistent stressor th

We are seeking a PhD student to join our team for a newly funded three-year interdisciplinary project "Global change, freshwater snails and ecosystem effects: Will smaller invasive species dominate?"  Project Overview The project will investigate the mechanisms and effects of species invasions along environmen

The Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position Postdoctoral researcher in Tumor microenvironment & metabolism in t

Academic position at the Department of Forest Botany, Dendrology and Geobiocenology, Faculty of Forestry and Wood Technology Research area: biostatistics, computational biology, and integration of multidimensional data in plant genetics, physiology, phytochemistry, and environmental metabolomics The De

We are looking for a research assistant/technician to join the group of Iva Mozgová, https://mozgovalab.umbr.cas.cz/ at the Biology Centre CAS in České Budějovice, CZ. We are an international research group with interest in the functio

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Technik/technička/laborant/laborantka se zaměřením na onkologii Typ systemizovaného místa: Technik III – Odborný laborant. Předpokládaný nástu

Děkan Fakulty zdravotnických studií Univerzity J. E. Purkyně v Ústí nad Labem vypisuje výběrové řízení na obsazení místa akademického pracovníka/pracovnice na Katedře ošetřovatelství   Počet volných míst/Pozice/Obor činnosti: 1 x akademický pracovník/pracovnice na Kated

The Institute of Experimental Medicine of the CAS (IEM CAS) is looking for a suitable candidate for the position of Postdoctoral Researcher for the Department of Genome Biology. Background We investigate the mechanisms underpinning DNA dama

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Lektor / lektorka se zaměřením na stomatologii / endodoncii Předpokládaný nástup: březen 2026 nebo dle dohody Předpokládaný úvazek: úvazek 0,1 dle dohody

Workplace: Department of Experimental Biology, Faculty of Science, Masaryk University in Brno, Czech Republic Type of Contract: temporary position with 3-year contract (with possible extension), academic Working Hours: 0,3 FTE (part-time employment of 12 hours per week) Expected St

Raman optical activity is a dynamically evolving vibrational spectroscopy, suitable, for example, for structural studies of biomolecules. Spectral interpretations are usually based on molecular dynamics and quantum-chemical methods. These need to be adapted for a particular experiment. We will focus on theoretical description of resonance and...

Recent discoveries of non-canonical RNA caps, such as NAD and CoA, have led to a fundamental reassessment of the structural diversity of RNA across all domains of life. In our research group, we have identified an entirely new class of RNA caps—dinucleoside polyphosphates (NpnN)—present in both bacterial and eukaryotic cells. This discovery...

The recent discovery of non-canonical RNA caps, such as NAD and CoA, has fundamentally changed our understanding of the structural and functional diversity of RNA in all types of cells. In our laboratory, we have recently identified a new type of RNA cap in mammalian cells—diadenosine tetraphosphate (Ap4A). Ap4A has been known for several...

Quantum nanosensors offer significant advantages over classical sensors, including high sensitivity and resolution. One type of such quantum nanosensor is photoluminescent nanoparticles, whose detection is based on monitoring luminescence changes in response to external stimuli. The goal of the project is to read optical nanosensors using pulsed...

Photoluminescent nanodiamonds represent a novel type of quantum biosensor that exploits changes in luminescent properties in response to external stimuli. Compared to classical sensors, they offer the benefits of high sensitivity and resolution but are often nonspecific. The aim of the project is to chemically functionalize these sensors for...

The topic of the dissertation will be the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified XNA oligonucleotides will be prepared and tested as potential therapeutics.

The topic of the dissertation will be the enzymatic synthesis of hypermodified xeno-nucleic acids and their use in aptamer selection. It will be necessary to develop enzymatic synthesis of modified XNA libraries, selection of binding sequences, reverse transcription into DNA and sequencing. The goal will be the development of stable aptamers...

The aim of the thesis will be to synthesize PROTACs for several kinases, which are validated targets in oncology and in CNS disorders. It will be focused on linker optimization, selection of ligase ligands and specificity for target kinase. Our recently developed highly selective small molecule heterocyclic kinase inhibitors will serve as a...

The aim of the thesis will be the development of an efficient enzymatic synthesis of oligonucleotides on solid support. Diverse solid supports and linkers will be tested for attachment of templates and will be used for primer extension with either denaturaion or cleavage of the resulting oligonuclotides by endonucleases. Methods will be then...

The aim of the thesis will be the enzymatic synthesis of DNA bearing diverse sugars or glycans. The project will start with synthesis of diverze sugar- or glycan-linked dNTPs and their enzymatic incorporation into DNA. It will be followed by development of site-specific methods and syntheses of DNA probes bearing glycans at specific positions for...

The dissertation will focus on the mechanistic principles underlying photogearing at the molecular scale, i.e. the conversion of a light-driven primary motion into a mechanically coupled secondary rotation. While many molecular systems undergo photoinduced conformational changes, only a limited number enable controlled transmission of motion...

Our group recently developed nucleophilic aromatic substitutions for synthesis of drug-like atropisomers, chiral conformational isomers originating from restricted single bond rotation. In this context, we discovered a fluoride-catalyzed strategy that is remarkably efficient. In this PhD thesis, we will explore this reactivity for synthesis of...

Critical raw materials such as rare earth elements and other strategically important metals are indispensable for modern technologies, yet are increasingly difficult to secure in a sustainable manner. This Ph.D. project will focus on the rational design and synthesis of tailored chelating agents capable of selectively binding and recovering the...

Excited state multiplicity plays a critical role in governing photochemical reactivity. Most of the excited organic molecules can exist either in the singlet or triplet excited state. Singlets are typically short-lived (~ns) and exhibit zwitterionic character, whereas triplet excited states, with their diradical-like nature, are significantly...

The multiplicity of excited states in organic photochemistry is governed by electron spin and its interactions. Excited molecules most commonly occur in singlet or triplet states; interconversion between them and the resultant reactivity are controlled by spin-selection rules and the magnitude of spin–spin interactions. In particular,...

The aim of the project is to develop the synthesis of new warped and chiral nanocarbons such as helical pi-conjugated macrocycles or cycloarenes. The chiral compounds will be prepared in optically pure form by resolution of racemates or by asymmetric synthesis. Their (chir)optical properties, self-assembly in 2D/3D space, aromatic character, and...

As part of the doctoral project, a new class of helically chiral metal complexes for enantioselective catalysis will be developed. The main part of the work will focus on their design and synthesis. The catalytic potential of the prepared systems will then be verified on model enantioselective transformations catalyzed by transition metals, in...

The aim of the project is to prepare new helical TADF and excimer luminophores derived from helicenes and to study their chiroptical properties in solution and thin films (in particular circularly polarized luminescence) in order to identify suitable materials for future CP-OLED design. Universit

Workplace: Department of Department of Experimental Biology, Faculty of Science, Masaryk University, Czech Republic Type of Contract: temporary position with 1-year contract with possible extension, academic Working Hours: 0,6 FTE (part-time employment of 24 hours per week) Expecte

Pracovní pozice vznikla za finanční podpory Evropské unie v rámci projektu LERCO s reg. číslem CZ.10.03.01/00/22_003/0000003, prostřednictvím Operačního programu spravedlivá transformace Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení k obsazení místa: Laborant/techni

Doctoral study program: Biomedical Sciences Specialization: Molecular Medicine Supervisor: Mgr. Veronika Šandová, Ph.D. Topic title: Therapy-induced changes in CD20 expression and microenvironmental interactions in chronic lymphocytic leukemia Annotation:

Doctoral study program: Biomedical Sciences Specialization: Molecular Medicine Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic title: Long non-coding RNAs (lncRNAs) in microenvironmental interactions of B cell chronic lymphocytic leukemia Annotation:

Doctoral study program: Life Sciences Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Overcoming the Endosomal Barrier: Design Principles of Fusogenic Proteins for Lipid Vesicles Annotation: Cancer remains one of the leading causes of mortality worldwide, claim

Doctoral study program: Life Sciences Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Designing Coiled-Coil Peptides for Controlled Membrane Fusion and Intracellular Delivery Annotation: Most approved drugs act on cell-surface targets or enter cells passively.

Doctoral study program: Life Sciences Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Consultant: Miroslav Boudny, Ph.D. Topic title: Lymphoid microenvironment models and their use to study targeted therapy and resistance in B cell malignancies Annotation:

Děkan Lékařské fakulty Ostravské univerzity vypisuje výběrové řízení na obsazení pracovního místa Asistent / Asistentka se zaměřením na epidemiologii a ochranu veřejného zdraví Předpokládaný nástup: únor 2026 nebo dle dohody Před

Doctoral study program: Life Sciences Supervisor: prof. Mgr. Richard Štefl, Ph.D., Topic title: Deciphering the Argonaute Loading Mechanisms in RNA-Silencing Pathways Annotation: Small RNAs are master regulators of gene expression in animals and plants. They guide Argo

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time /combined Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Mgr. Václav Šeda, Ph.D. Consulta

Doctoral study program: Life Sciences Form of study: doctoral full-time Supervisor: Mgr. Michal Šmída, Ph.D. Topic title: The role of mitochondria exchange through tunnelling nanotubes in the regulation of CAR-T cell activity Annotation: CAR-T cell

Come to CEITEC MU in Brno and join us! We are passionate chemists at CEITEC Masaryk University looking for Two PhD Candidates/Students in Molecular Strategies for Anticancer Drug Delivery       About this position: We are seeking two highly motivated PhD candidates with a strong interest in understanding chemo

Come to CEITEC MU in Brno and join us! We are passionate chemists at CEITEC Masaryk University looking for PhD Candidate/Student in Computational Quantum Chemistry & Spectroscopy          About this position: Do you have a passion for understanding the electronic structure of molecules?

Tajemník Přírodovědecké fakulty Masarykovy univerzity vypisuje výběrové řízení na obsazení pracovního místa: Výzkumník/výzkumnice Pracoviště: RECETOX, Přírodovědecká fakulta Masarykovy univerzity v Brně Pracovní poměr: na dobu určitou s úvodní pracovní smlouvou

Doctoral study program: Life Sciences Supervisor: RNDr. Radek Marek, Ph.D. Topic title: Junctions in noncanonical forms of nucleic acids Annotation: The project is focused on detailed structural characterization of short oligonucleotides in noncanonical forms clipped to

Doctoral study program: Life Sciences Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Lipid nanoparticles in drug delivery Annotation: With nearly 10 million lives claimed annually, cancer remains one of the leading causes of mortality worldwide, highlighting t

Doctoral study program: Life Sciences Supervisor: RNDr. Petr Tesina, Ph.D. Topic title: Mechanisms of human translation control Annotation: Co-translational quality control is triggered as a response to translational stalling events. Yet, different molecular mechanisms

Doctoral study program: Life Sciences Supervisor: Pavel Plevka Topic title: Mechanisms of neutralization of TBEV by polyclonal and monoclonal antibodies Annotation: Tick-borne encephalitis virus (TBEV) is a medically significant flavivirus causing severe neurological di

Doctoral study program: Life Sciences Supervisor: Dr. Dalibor Blazek, PhD. Topic title: Mechanistic Roles of Cyclin-Dependent Kinase 12 (CDK12) in Transcription Regulation and Cancer Biology. Annotation: CDK12 is a transcriptional cyclin-dependent kinase (CDK) found mut

Doctoral study program: Life Sciences Supervisor: Lukas Trantirek, Senior Research Group leader (UCO: 8725) Consultant: Anirban Ghosh, Senior Researcher (UCO: 246285), Topic title: Molecular insights into the G-quadruplex–helicase interactome and its functional implicati

Doctoral study program: Life Sciences Supervisor: Lukas Trantirek, Senior Research Group leader (UCO: 8725) Consultant: Silvie Trantirkova, Senior Researcher (UCO: 118502), Topic title: Protein in-cell NMR Spectroscopy in 3D Stem Cell-Derived Human Organ Models

Doctoral study program: Life Sciences Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Consultant: Vaclav Seda, Ph.D. Topic title: REGULATION OF CELL MIGRATION IN B CELL LEUKEMIAS AND LYMPHOMAS Annotation: The project goal is to understand the molecul

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Mgr. Miroslav Boudny, Ph.D. Consultant:

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic ti

Doctoral study program: Biomedical Sciences Study plan: Molecular Medicine Form of study: doctoral full time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: RNDr. Josef Večeřa, Ph.D. Topic title:

Doctoral study program: Life Sciences Supervisor: Pavel Plevka Topic title: Structural characterization of leptophage replication cycle Annotation: Despite decades of study, important aspects of phage replication cycles, such as the mechanism of genome delivery, initiat

Doctoral study program: Life Sciences Supervisor: Pavel Plevka Topic title: Structure-guided phylogeny of tailed bacteriophages Annotation: Tailed phages are a diverse group of viruses abundant in all econiches as revealed by recent metagenomic studies. In the past ten