Background ****************************************************************************************** * ****************************************************************************************** Obesity, type 2 diabetes and related complications represent the major health challenge gl largely impact societies, as fully demonstrated during the COVID-19 pandemic, which dispro affected patients with obesity and/or diabetes. Even though the incidence of diabetes is d urban areas when compared to rural ones, diabetes management and access to proper care are low-income and aged urban inhabitants. Prevention and early treatment of the disease, before complications arise, have the highes impact. However, there is an unmet need for effective, affordable non-pharmacological meas implementation. Variability in metabolic responses to lifestyle interventions is one reaso predictors of successful metabolic response, identifying surrogate markers of response and the interventional programme delivery, will help identify future directions at the verge o public health care. The project will bring together leading European scientists for a symposium combining inte and educational workshops, spanning from basic research into the multi-omics predictive pa balance and host-microbiome interactions, over the diet and exercise intersection to epide policymaking. The ultimate aim is to identify the crucial steps to be taken to maximize th lifestyle interventions: how to personalize them and how to increase the implementation ef sustainably in urban societies. The aim to identify ways to effective prevention and early treatment of disabilities from diseases and to support the resilience of the European population, namely those vulnerable environments. To get to the goal the project would set up an informal research/education p would formulate future research directions for personalized lifestyle interventions and to prospects of future PhD topics. We would like to invite you for an introductory symposium in Prague that would combine: 1.invited state-of-the art talks on crucial aspects of the lifestyle intervention and its 2.focused group works on specific tasks on future research and implementation strategies a 3.opportunities to present research outputs for early career researchers from partner univ get information about possible mobilities